DAFLON
500
Content
Micronized purified flavonoidic fraction (diosmin 450 mg, hesperidin 50
mg).
Description
Each tablet
contains micronized flavonoid fraction 500 mg (diosmin 450 mg and
hesperidin 50 mg).
Daflon 500 also contains the following excipients: Carboxymethylcellulose
sodium, microcrystalline cellulose, gelatin, magnesium stearate, talc,
white beeswax, glycerol, hydroxypropylmethylcellulose (2910), polyethylene
glycol 6000, sodium lauryl sulfate, yellow iron oxide, red iron oxide and
titanium dioxide.
The innovation with Daflon 500 consists of the micronization of its active
constituent from particles of 30-60 microns to particles of <2 microns.
This new and optimized form allows Daflon 500 to increase venous tone from
the first 2-tab dose and by the 1st hour and provides Daflon 500 with
added clinical efficacy.
Actions
Daflon 500 is a phlebotonic drug
and a vascular protecting agent.
The efficacy of Daflon 500 is accounted for by its specific action on the
principal elements of venous disease.
Daflon 500 is phlebotonic: It reinforces venous tone by prolonging the
activity of parietal noradrenaline. Thus, Daflon 500 decreases venous
capacitance, venous distensibility and venous emptying time.
Daflon 500 protects the microcirculation by fighting the
microcirculation-damaging process; it combats venous inflammation by
decreasing leukocyte activation, and as a consequence, by inhibiting the
release of inflammatory mediators, principally free radicals and
prostaglandins. Thus, Daflon 500 normalizes capillary permeability and
strengthens capillary resistance.
Daflon 500 acts on the lymphatic system: It improves lymphatic drainage by
increasing lymph flow and lymph oncotic pressure. This action on the
lymphatic system associated with a phlebotonic and vasculoprotective
effect, explains the activity of Daflon 500 on CVI-associated edema.
Double-blind, placebo-controlled studies have demonstrated Daflon 500's
efficacy on chronic venous insufficiency. Daflon 500 significantly
improves disabling symptoms of venous insufficiency which affect everyday
active life: Heavy legs, pain, heat sensation, edema, functional
impairment, nocturnal cramps and restless legs.
In addition to conventional compression therapy, Daflon 500 has also
demonstrated to cure 3 times as many venous leg ulcers as placebo, and to
accelerate their complete healing.
Daflon 500 is highly effective in the treatment of chronic hemorrhoidal
disease. It significantly improves subjective symptoms and objective
signs, eg anal discomfort, pain, redness, anal discharge, proctitis,
tenesmus, pruritus, erythema and bleeding. Daflon 500 also significantly
reduces the frequency, severity and duration of acute hemorrhoidal
attacks.
Indication
Organic &
functional chronic venous insufficiency of the lower limbs; heavy legs,
pain, nocturnal cramps. Hemorrhoidal disease, acute hemorrhoidal attacks.
Dosage
Chronic venous
insufficiency 2 tab daily. Acute hemorrhoidal attacks 6 tab/day
for the 1st 4 days, then 4 tab/day for 3 days, 2 tab thereafter. Chronic
hemorrhoids 2 tab daily.
Special
Precaution Lactation.
Adverse
Reaction Minor
GI & neurovegetative disorders.
Storage
Presentation
& Packing
| Form |
Packing
/ Price |
Photo |
| Coated
tab |
30's |
|
|
